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Cardiogenic Shock Cyrus Vahdatpour, MD; David Collins, MD; Sheldon Goldberg, MD, FACC C ardiogenic shock (CS) is a common cause of mortality, and management remains challenging despite advances in therapeutic options. CS is caused by severe impairment of myocardial performance that results in diminished cardiac. Myocardial Depressant Factor (MDF) is a small peptide circulating in the blood of all mammalian species tested in a variety of shock states including endotoxic, hemorrhagic, cardiogenic, bowel ischemic, acute pancreatitis, burn, and traumatic shock. MDF is produced by the action of proteolytic enzymes released by the ischemic by: The lysosomal protease--myocardial depressant factor system in circulatory shock. Lefer AM, Glenn TM Adv Exp Med Biol, 33(0), 01 Jan Cited by: 6. Cardiogenic shock is a shock state in which abnormal car- diac function plays a major role in the genesis of the shock syn- drome. Etiology of the Shock Syndrome A number of common cardiovascular diseases can lead to cardiogenic shock (Table I). The most common underlying fac- tor in the development of cardiogenic shock (CGS) is abnor-.
While several genetic factors may contribute to susceptibility to cardiogenic shock, no direct genetic link has been documented. Tumor necrosis factor (TNF)-alpha variants have been associated with severe heart rphisms in several genes may be predictors of survival: TNF-alpha, interleukin (IL)-6, IL, transforming growth factor (TGF)-beta, and interferon (IFN)-gamma cytokine. Estimates of mortality related to cardiogenic shock are 50% making this one of the most challenging types of shock to treat (Sole, ). However, advancements in diagnoses and treatment over the years have greatly increased the survivability of cardiogenic shock. There are numerous conditions that contribute to cardiogenic shock however; acute. Abstract. Myocardial depressant factor (MDF) was initially identified by Brand and Lefer 1 in in the circulating blood of cats subjected to hemorrhagic shock. This substance was characterized as a potent negative inotropic agent then it has been described in many forms of shock, including burn 2, cardiogenic 3,4, endotoxic 5, acute pancreatitis 6 and splanchnic ischemia 7,8 shock. _____ and _____ is thought to play a role in depressing myocardium (in cardiogenic shock) Myocardium infraction and TNF It has been hypothesized that the myocardial depression factor produces severe but potentially _______ myocardial depression, ventricular dilation, and decreased left ventricle ejection fraction and diastolic pressure.
Cardiogenic shock (CS) is a common cause of mortality, and management remains challenging despite advances in therapeutic options. CS is caused by severe impairment of myocardial performance that results in diminished cardiac output, end‐organ hypoperfusion, and hypoxia. 1 Clinically this presents as hypotension refractory to volume resuscitation with features of end‐organ hypoperfusion. Cardiogenic shock occurs in about 4% of patients following STEMI. 12 Risk factors for cardiogenic shock include extensive infarction, anterior infarction, previous myocardial infarction, low ejection fraction, and multivessel coronary artery disease. Shock is more common in myocardial infarctions that occur in the elderly, in diabetics, and in. Cardiogenic shock is a major, and frequently fatal, complication of a variety of acute and chronic disorders that impair the ability of the heart to maintain adequate tissue perfusion. Cardiogenic shock is the clinical demonstration of profound depression of myocardial contractility, be it left, right or biventricular.